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Concrete is the most widely used construction material in the world and testing of concrete specimens plays an important role in assessing structural strength and durability. This study presents a detailed comparison between Destructive Tests (DT) and Non-Destructive Tests (NDT) conducted on M20 and M25 grade concrete in which fine aggregate (sand) is partially replaced with Quarry Dust (QD) at 0%, 5%, 10%, 20%, and 30% by weight. Destructive tests included compressive strength and split tensile strength, while non-destructive tests included the Rebound Hammer Test (RHT) and the Ultrasonic Pulse Velocity Test (UPV). Results demonstrate that replacing sand with 20% quarry dust yields the highest compressive and tensile strengths for both M20 and M25 grades. A good correlation was found between compressive strength, rebound number, and ultrasonic pulse velocity, confirming the reliability of NDT methods for concrete strength assessment. Addition of quarry dust beyond 20% reduced workability and strength due to increased water absorption.